CHEM 209 |
Degrees:
American Cancer Society Postdoctoral Fellow, Stanford University 1993-96
Ph.D., The Pennsylvania State University, 1993
B.A., Virginia Tech, 1987
Research Interests:
natural product synthesis
Research:
The McIntosh research group is involved in synthetic organic chemistry, including both synthetic methods development and total synthesis of complex natural products. Current targets include sclerophytin-A, massileunicellin-I and antascomicin-B.
Natural product total synthesis is the reconstruction of a naturally occurring compound in the laboratory starting from simple, commercially available materials. There are several goals of natural products total synthesis:
- to prove or disprove the proposed structure of the natural product
- to provide additional quantities of the natural product for biological testing
- to learn the unique chemistry of the natural product
- to modify the natural product to improve its biological profile, e.g. improve
potency, decrease side effects, increase metabolic stability, increase solubility,
etc.
- to discover new organic chemistry
In the course of our investigations, we have developed a number of new variants of organic reactions, including the Claisen rearrangement, the allylic diazene rearrangement, and the cycloaldol reaction. For more detailed information on these and other projects in the McIntosh group, visit the group home page (link below).
McIntosh Research Group Homepage