CHEM 209 |
Degrees:
American Cancer Society Postdoctoral Fellow, Stanford University 1993-96
Ph.D., The Pennsylvania State University, 1993
B.A., Virginia Tech, 1987
Research Interests:
natural product synthesis
Research:
The McIntosh research group is involved in synthetic organic chemistry, including both synthetic methods development and total synthesis of complex natural products. Two of our current targets are eleutherobin and spirofornabuxine. Eleutherobin is a cytotoxic anti-cancer compound isolated from a soft coral. Spirofornabuxine is an unusual alkaloid isolated from the eurasian shrub Buxus sempervirens.
Our approach to these and other target molecules employs the Claisen rearrangement as one of the key steps. In addition to use of the Claisen rearrangement in natural product synthesis, we are also investigating new variations of the rearrangement itself. We have recently found that the Ireland Claisen rearrangement of bis-allyl silylketene acetals derived from cyclohexenones undergo regio- and stereoselective Claisen rearrangement to yield stereodefined alkylidene cycloalkenes. For more detailed information on these and other projects in the McIntosh group, visit the group home page (link below).