Gawley, Robert
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Robert E. Gawley CHEM 114 Degrees:B.S. Stetson University, 1970 Awards and Honors:Fogarty Senior International Fellow, ETH-ZÜrich, 1993-94 |
Research Interests:
There are several areas of emphasis in my group: asymmetric synthesis using chiral organometallics; development of new synthetic methods; synthesis of new nanomaterials for biomedical imaging.
Publications/Presentations:
"Visible Fluorescence Chemosensor for Saxitoxin" Robert E. Gawley, Hua Mao, M. Mahbubul Haque, John B. Thorne, and Jennifer S. Pharr, J. Org. Chem. 2007, 72, 2187-2191.
"Configurational and Conformational Effects on Tin-Lithium Exchange in ±-Aminoorganostannanes by Rapid-Injection NMR", R. Klein and R. E. Gawley, J. Am. Chem. Soc. 2007, 129, 4126.
"Structures of Pahayokolides A and B, Two Cyclic Peptides from a Lyngbya sp." T. An, T. K. S. Kumar, M. Wang, L. Lu, J. O. Lay, Jr., R. Liyanage, J. Berry, M. Gantar, V. Marks, R. E. Gawley, and K. S. Rein, J. Nat. Prod., 2007, 70, 730-735.
"Stereoselective [2,3]-Sigmatropic Rearrangements of Unstabilized Nitrogen Ylides" R. E. Gawley and K. Moon Org. Lett. 2007, 9, 3093-3096.
"Dynamics of Saxitoxin Binding to Saxiphilin C-lobe Reveals Conformational Change" P. Lewis, I., R. E. Gawley, R. Henry, A. Kight, J. O. Lay, Jr., R. Liyanage, J. McLachlin Toxicon 2008, 51, 208-217.
"The barrier to enantiomerization of N-Boc-2-lithopyrrolidine: the effect of chiral and achiral diamines" Taher I. Yousaf, Roger L. Williams, Iain Coldham, and Robert E. Gawley Chem. Commun. 2008, 97-98.
“Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine” Timothy K. Beng, Taher I. Yousaf, Iain Coldham, and Robert E. Gawley J. Am. Chem. Soc. 2009, 131, 6908-6909.
“The Barrier to Enantiomerization and Dynamic Resolution of N-Boc-2-lithiopiperidine and the Effect of TMEDA” Iain Coldham, Daniele Leonori, Timothy K. Beng, Robert E. Gawley, Chem. Commun. 2009, 5239-5241.
“Overview of Carbanion Dynamics and Electrophilic Substitutions in Chiral Organolithium Compounds”, R. E. Gawley, in “Stereochemical Aspects of Chiral Organolithium Compounds”, R. E. Gawley, Ed., Vol. 26 in Topics in Stereochemistry; pp. 93-133; Verlag Helvetica Chimica Acta: Zürich, 2010.
“Signal Amplification in a Microchannel from Redox Cycling with Varied Electroactive Configurations of an Individually-Addressable Microband Electrode Array” Penny M. Lewis, Leah B. Sheridan, Robert E. Gawley, Ingrid Fritsch, Anal. Chem., 2010, 82, 1659-1668.
“Novel modulator of NaV1.1 and NaV1.2 Na+ channels in rat neuronal cells” H. Mao, L. A. Fieber, R. E. Gawley, ACS Med. Chem. Lett. 2010, 1, 135-138.
“Highly Enantioselective Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine: Synthesis of (R)-(+)-Pipecolic acid, (S)-(–)-Coniine, (S)-(+)-Pelletierine, (+)-β-Conhydrine, (S)-(–)-Ropivacaine, and Formal Synthesis of (–)-Lasubine II and (+)-Cermizine C” Timothy K. Beng and Robert E. Gawley, J. Am. Chem. Soc., 2010, 12216-12217. This article was highlighted in SYNFACTS 2010, 1328.
“Application of Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine to the Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines” Timothy K. Beng and Robert E. Gawley, Org. Lett., 2011, 13, 394-397.
“Formal synthesis of the bisbenzylisoquinoline alkaloid berbamunine by asymmetric substitution of chiral organolithium compounds” Robert E. Gawley and Gregory A. Smith, Arkivoc 2011, 167-179.