Gawley, Robert
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Robert E. Gawley CHEM 114 Degrees:B.S. Stetson University, 1970 Awards and Honors:Fogarty Senior International Fellow, ETH-ZÜrich, 1993-94 |
Research Interests:
There are several areas of emphasis in my group: asymmetric synthesis using chiral organometallics; development of new synthetic methods.Publications/Presentations:
“Overview of Carbanion Dynamics and Electrophilic Substitutions in Chiral Organolithium Compounds”, R. E. Gawley, in “Stereochemical Aspects of Chiral Organolithium Compounds”, R.E. Gawley, Ed., Vol. 26 in Topics in Stereochemistry; pp. 93-133; Verlag Helvetica Chimica Acta: Zürich, 2010.
“Signal Amplification in a Microchannel from Redox Cycling with Varied Electroactive Configurations of an Individually-Addressable Microband Electrode Array” Penny M. Lewis, Leah B. Sheridan, Robert E. Gawley, Ingrid Fritsch, Anal. Chem., 2010, 82, 1659-1668.
“Novel modulator of NaV1.1 and NaV1.2 Na+ channels in rat neuronal cells” H. Mao, L. A. Fieber, R. E. Gawley, ACS Med. Chem. Lett. 2010, 1, 135-138.
“Highly Enantioselective Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine: Synthesis of (R)-(+)-Pipecolic acid, (S)-(–)-Coniine, (S)-(+)-Pelletierine, (+)-β-Conhydrine, (S)-(–)-Ropivacaine, and Formal Synthesis of (–)-Lasubine II and (+)-Cermizine C” Timothy K. Beng and Robert E. Gawley, J. Am. Chem. Soc., 2010, 12216-12217. This article was highlighted in SYNFACTS 2010, 1328. “Formal synthesis of the bisbenzylisoquinoline alkaloid berbamunine by asymmetric substitution of chiral organolithium compounds” Robert E. Gawley and Gregory A. Smith, Arkivoc 2011, 167-179. “Design and Synthesis of C2-Symmetric N-Heterocyclic Carbene Precursors and Metal Carbenoids” Abigail Albright, Daniel Eddings, Regina Black, Christopher J. Welch, Nikolay N. Gerasimchuk, Robert E. Gawley J. Org. Chem. 2011, 76, 7341-7351. “NHC-catalyzed dehydrogenative self-coupling of diphenylsilane: a facile synthesis of octaphenylcyclotetra(siloxane)” Abigail Albright and Robert E. Gawley, Tetrahedron Lett. 2011, 52, 6130-6132. “Application of a C2-symmetric Copper Carbenoid in the Enantioselective Hydrosilylation of Dialkyl and Aryl Alkyl Ketones” Abigail Albright and Robert E. Gawley J. Am. Chem. Soc. 2011, 133, 19680-19683. “Catalytic Dynamic Resolution Applied to the Synthesis of 2,6-Disubstituted Piperidines: Preparation of (+)-Lupetidine and (–)-Epidihydropinidine” Timothy K. Beng and Robert E. Gawley, Heterocycles 2012, 84, 697-718. Principles of Asymmetric Synthesis, 2nd Edition, R. E. Gawley and J. Aubé, Elsevier: Oxford, 2012. “Synthetic Applications and Inversion Dynamics of Configurationally Stable 2-Lithio-2-aryl-Pyrrolidines and -Piperidines” Timothy K. Beng, Jin Sun Woo, Robert E. Gawley J. Am. Chem. Soc. 2012 134, 14764-14771. “Dynamics of Catalytic Resolution of 2-Lithio-N-Boc-piperidine by Ligand Exchange” Timothy K. Beng, William S. Tyree, Trent Parker, Chicheung Su, Paul G. Williard, and Robert E. Gawley, J. Am. Chem. Soc., 2012, 134, 16845-16855.
“Application of Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine to the Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines” Timothy K. Beng and Robert E. Gawley, Org. Lett., 2011, 13, 394-397.